http://congdong.bancongxanh.com/34485.php For one thing, different preparations may contain different amounts of phytochemicals and adulterants. Of particular concern are reports of seizures, which increased fivefold in Thailand between and Kratom effects on liver health may also occur after two to eight weeks of regular use. Heavy kratom users might notice a hyperpigmentation or darkening of the cheeks due to over-stimulation of melanocytes. Some other issues linked to kratom use, albeit more rarely, include sleep problems, hypotension, tremors, temporary erectile dysfunction, sweating, hair loss, dry mouth, and anorexia.
Kratom should be avoided by pregnant or breastfeeding women. Aside from the potential health issues associated with kratom use alone, limited evidence suggests infants may also become addicted to the substance via passive intake either in the womb or via breast milk —to the point of suffering withdrawal symptoms once the substance is removed. Evidence suggests psychosis, including paranoid delusions, hallucinations, and confusion, may be caused by regular use spanning a decade or more.
While a number of human fatalities have been linked to kratom use, there are usually other substances present. A study in identified a lethal kratom dosage in mice, or at least a lethal dose of the extracted alkaloids injected intravenously i. When administered orally, the LD50 for mitragynine in mice was No lethal dose was observed for 7-hydroxymitragynine given orally.
So can you overdose on kratom? Probably not—at least not by accident. These findings appear to uphold the broad consensus among users that a lethal kratom dosage using powdered leaf products as opposed to resins or extracts of unknown potency would be physically impossible to reach. How much kratom to take depends on your physiology, tolerance, and other factors. Chances are that as a newbie your tolerance is nil, but there may be a cross-tolerance effect with other opioids. In any case, the recommended starting dose is one to two grams.
Ideally, you should measure out your dose on a digital scale. Capsules tend to contain between and mg, so you may need one to three for a starting dose. For the pros and cons of each method—and the best way to take kratom—see FAQ. The dosage guide on the kratom Reddit wiki suggests waiting minutes after your first dose to see how it affects you. Then, if you feel you need more, take up to one more gram.
After waiting another minutes, take up to one more final gram if desired. You should find your optimal dose pretty soon. Generally speaking, a moderate dose of plain dried leaf powdered is g, but anything above 5 g is considered strong. On an empty stomach, kratom effects are noticeable from around the minute mark, gradually building in intensity and peaking for two to four hours.
Stronger doses may have a shorter onset. Lower doses are often more stimulating. They may be characterized by increased motivation, talkativeness, and sociability, along with a feeling of euphoria and physical energy. Other disagreeable kratom effects—including sweating, nausea, dizziness, and dysphoria—can also be experienced during the onset period, but they usually give way in time.
At the higher, sedative dose ranges, kratom users report a diminished sensitivity to physical and emotional pain, and a feeling of general contentedness. Ethnobotanist and author Daniel Siebert likened this to the state prized by 19th-century Romantics, who used opium to keep one foot in dreamland and the other in the real world. Additional kratom effects might include mild visuals both open- and closed-eye , a warming sensation, increased empathy, and possibly sexual arousal. The pupils are likely to constrict if they change size at all.
Many find that sex on kratom lasts longer, but that it can also feel impossible to climax. Erectile enhancement is common, but so is erectile dysfunction. Frequent use and higher doses can substantially diminish libido—sometimes completely. But many seem to enjoy combining sex and kratom; some men take it to increase the enjoyment of their partner even if it means sacrificing their own.
Any nausea that arises can be managed by keeping still until it passes. Swallowing kratom gradually can help too, however tempting it is to knock it back in one gulp to avoid the bitter taste. Driving and other potentially dangerous activities should be avoided—even if you feel stimulated. The effects of kratom can change from stimulant to sedative without warning, so sometimes just turning on the stove could be risky. New kratom users should start with a low dose, precisely weighed out on an accurate digital scale. The same goes for more experienced kratom users trying a new strain, due to the variability between them.
Another important consideration is the risk of addiction with chronic long term kratom use. Setting a personal limit of once or twice a week or ideally once or twice a month can be useful. Kratom withdrawal symptoms can last for up to two to three weeks, although the purely physical symptoms tend to abate in three days. Although generally safe on its own, kratom interactions with medications and other substances are potentially problematic. Mixing kratom and opiates together, for example, can lead to fatal respiratory depression.
It can also lead to vomiting while unconscious, resulting in suffocation.
Interactions between kratom and oxycodone OxyContin , kratom and hydrocodone, kratom and tramadol, kratom and DXM, etc. The same goes for benzodiazepines, e. Klonopin and kratom, Valium and kratom, Xanax and kratom, etc. For more information, see the kratom Reddit group. Some also find it helps to relieve an Adderall comedown. However, it may be best to stagger your intake of each, for example by taking kratom several hours after Adderall. Many people combine kratom and weed for enhanced relaxation effects. As with other substances, however, you might want to stagger your intake.
Holliday E. To truly understand what audiences know, think and feel, set aside assumptions and preconceived notions. You should find your optimal dose pretty soon. Since , investigators have tested millions of genetic variations polymorphisms in GWASs, trying to establish the genetic determinants of chronic diseases, such as coronary artery disease, type 2 diabetes, stroke, multiple sclerosis, breast cancer, 13 , 14 schizophrenia, 15 bipolar disorder, 16 , 17 rheumatoid arthritis, 18 , 19 Crohn disease, 16 , 20 and Alzheimer disease. Cancel Delete comment.
One recommendation is to eat some food in between taking kratom and cannabis to avoid feeling faint or lightheaded. It could potentially lead to respiratory failure. Rotating strains throughout the week so that no strain is taken on two consecutive days supposedly circumvents tolerance. While different strains have differing levels of the active indole alkaloids, those same alkaloids are nonetheless present in all. Admittedly that was just an estimate from one particular region of Ohio, but similar claims are repeated elsewhere.
But a quick search of the kratom Reddit group returns very few posts on injection and the AKA forum simply ridicules and dismisses the idea. In April , a government study appeared to confirm a rise in kratom overdose deaths. According to the report, between July and December , kratom killed 91 people.
However, of these 91 people only seven took kratom on its own. The overwhelming majority combined it with other drugs. Meanwhile, prescription opioids remain one of the leading causes of overdose death in America, killing more than 17, people in For more on this, check here. Daniel Siebert described it as one of the most effective herbal analgesics, second only to opium. Mitragynine, meanwhile, is seen as a potential replacement for codeine, offering comparable analgesic effects   without the fatal respiratory depression.
Kratom could eventually come to replace methadone in the treatment of heroin addiction     —especially given its relative ease of production, making it ideal for poor and developing countries. It can also be helpful for getting off prescription opioids. At least one study supports the growing use of kratom to manage anxiety and depression. Mice injected with mitragynine were found to have lower levels of corticosterone, a hormone involved in the regulation of stress responses and energy. Opinions on the best strains vary.
One of the best strains of kratom for depression is reportedly white Maeng Da. Many people lose weight while using kratom. Weight loss may instead be attributed to its anxiolytic or antidepressant effects eliminating cravings for junk food. It also promotes healthy lifestyle changes that lead to weight loss, such as getting more exercise and drinking less alcohol. Other conditions that kratom shows potential for include diarrhea,   chronic pain,   inflammation,  arthritis,  migraines,   and even cancer.
Some kratom users report that kratom can reduce social anxiety, and even improve sexual performance. Liberated from the confines of everyday thought patterns, people also find greater appreciation for being alive. There are conflicting reports as to how long kratom can be detected in the urine.
Some say as little as one day and others upwards of two weeks. Evidence suggests there may be a link between prolonged, regular kratom use or addiction and deluded thoughts. Kratom is apparently safe for most healthy individuals. Little is known about kratom and pregnancy  — but it can apparently be transmitted to fetuses in the womb, as well as babies via breastfeeding. The majority of kratom users probably buy kratom online. The same is true of the AKA forum. Going by kratom vendor reviews, however, some of the top kratom vendors and brands are in no particular order :     .
They have outlets in Chicago, St. Louis, Dallas, and Los Angeles. This term may be used to differentiate between natural and contaminated products, particularly when discussing the dangers. According to the AKA, for instance, kratom-related deaths are caused by kratom laced with adulterants—not botanical kratom alone. As a consumer, though, you may want to start growing kratom from seed to eliminate the risk altogether. It depends on state law.
But even in states where kratom is banned it may still be legal to grow for aesthetic purposes. The KratomGarden on Reddit is another good place to get advice and keep up with legal developments. You can easily find kratom seeds for sale online. You might find a grower with some to spare. Mitragyna speciosa seeds are light and flaky, similar to the seed pod as it dessicates.
So familiarize yourself with the way the seeds look to avoid sowing decaying plant matter—and to help avoid being sold the wrong ones. But even with fruit juice, the taste can lead to nausea. And stomach upset is common. However, they can also be expensive to buy, or else time-consuming if you make them yourself. The biggest con, though, is the fact they take longer to work.
Oblate discs are similar to capsules but supposedly faster-acting.
The third option is to brew your powder as a tea see below for recipe. Kratom tea effects have the fastest onset of any method, as well as reportedly the least stomach upset. Of course, the taste can still be unpleasant. However, some feel this adds to the allure. Whichever option you choose, generally the best way to take kratom powder is on an empty stomach.
You should also remember to stay hydrated. For more on this, see Precautions. The chances of addiction and physical harm increase too. For more information, see the kratom Reddit wiki and linked threads. Smoking kratom powder is unlikely to produce much of an effect due to the destruction of alkaloids when burnt. Vaping kratom, either as a powder or kratom vape juice, is also said to be ineffective.
Usually, dried kratom has to be brewed, filtered, and evaporated before it can be smoked. That said, smoking kratom resin as an alternative to opium is one of the traditional routes of administration. Chewing fresh leaves is a more viable alternative. Effects may be felt from as little as half of a large, 8-inch leaf or 1. You can follow this kratom tea recipe and find additional details at the kratom Reddit wiki.
Substances said to increase the effectiveness or strength of kratom include grapefruit juice, orange juice, and other acidic beverages.
Freezing individual doses is also said to increase their effects because the process breaks down cell walls. Be warned, however, that kratom potentiators will raise your tolerance proportionally. That said, there is some agreement generally as to what each strain is good for:  . There are many similarities between kava and kratom, leading some to confuse the two.
Whereas kratom is comparable to opiates, kava is like benzodiazepines e. Kava is more consistently sedating, in other words, not stimulating at lower doses like kratom. But its effects are often said to be milder. For more details, see Drug interactions. Phenibut and kratom have been favorably compared, although some feel that kratom is stronger or at least more consistent. Many prefer the reliability of kratom vs phenibut and warn against the rapid tolerance, dependence, and withdrawal effects of phenibut vs kratom.
Like kava, phenibut interacts with the GABA system. It tends to lower inhibitions and improve sleep. Some take phenibut and kratom together but this combination can be dangerous—not to mention highly addictive. Another possible kratom alternative, particularly for pain relief, is akuamma.
A better kratom substitute for managing depression, anxiety, and motivational issues may be kanna. In fact, the anxiolytic effects of kanna vs kratom are said to be stronger by some. This term only applies to opium derivatives. Kratom contains different alkaloids to those extracted from the opium poppy. It just has comparable receptor binding activity.
As an opioid receptor agonist, kratom has many of the same effects. But the motivational effect of kratom vs opiates sets this substance apart. And this difference between kratom and opiates extends to many other opioids too. The same can be said for kratom vs suboxone, for instance, kratom vs hydrocodone, and kratom vs oxycodone, among others. It may not be suitable for microdosing due to possible kratom liver damage. With frequent use, i. It may take several weeks of abstinence to return to normal sensitivity. Nor should it be mixed with depressants, including opiates, benzodiazepines, and alcohol, due to the risk of breathing problems and death.
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